USIS may make reference to:
USIS (company), a U.S. federal government contractor
USA Information Service, another name for america Information Agency
USA Immigration Service, a name sometimes found in days gone by, possibly both officially and informally at differing times, to make reference to at least one of the numerous U.S. national organizations of the professional branch that have carried out U.S. immigration regulation. (Today the main such company is the U.S. Immigration and Traditions Enforcement.)
Universal Space Program Standard, a business standard for docking of spacecraft.
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